Amino Acid Clock(AmiAge Clock)

Biological age, an indicator encapsulates the intricate interplay of genetic, environmental, and lifestyle factors that steer our growth, development, and aging process, has emerged as an accurate signature of health status. Amino acids play a crucial role in numerous physiological processes, including protein synthesis, metabolism, and cellular signaling, all of which are directly involved in the growth, development, and aging process. we developed an Amino Acid Age (AmiAge) clock using 18 plasma amino acids in several demographically diverse datasets (Atlas Project and UK Biobank, aged 1-89 years) and the random forest framework.

As lifelong processes exhibit significant heterogeneity due to the wide age range and the limited amount of information contained in peripheral amino acids, our AmiAge and many other age clocks usually overestimate younger ages and underestimate older ages. To enhance accuracy and balance, we developed an adjusted AmiAge using chronological age and statistical regression.

Our AmiAge clock is simple and easy to use. Try it now!

*Click the AmiAge clock button to perform AmiAge analysis.